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Abstract
Four dogs with spontaneous hyperadrenocorticism were treated with incremental administrations of o, p'-DDD. The initial dosage was 5mg/kg. Subsequent doses were administered at intervals of 3 to 5 days with a stepwise increase of 5mg/kg. After the dosage level reached 25 mg/kg, doses were raised at 2 to 3mg/kg increments. When such clinical signs as polyposia and polyuria had improved, the adrenocorticotropic hormone (ACTH) stimulation test confirmed the effectiveness of the therapy. The goal of treatment with o, p'-DDD was to achieve an ACTH stimulation result suggesting a normal range of responses. Possibly gradual o, p'-DDD dosage increases made it possible to achieve optimum individual dosages that resulted in high efficacy.
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