O impacto da histologia do carcinoma pulmonar na frequência das metástases ósseas

Abstract

ObjectivesLung cancer is the leading cause of oncological deaths, and bones are one of the most common sites of metastasis from this cancer type. The objective of this study was to evaluate the influence of lung carcinoma histology on the frequency of bone metastases. MethodsThis retrospective study evaluated medical records from 407 patients who were diagnosed with lung carcinoma between 2003 and 2012. The prevalence of bone metastases and their association with histological subtypes were evaluated using the chi‐squared test, odds ratios (ORs), and 95% confidence intervals (CIs). Overall survival was evaluated using the Kaplan‐Meier method. ResultsThe prevalence of bone metastases was 28.2% (n=115) and the spine was the most frequent site (98 metastases; 32.1%). Adenocarcinoma was the most common histological subtype of lung carcinoma (46.7%), and was significantly more frequent among patients with bone metastases (58.3% vs. 42.1%; p=0.003; OR=1.92; 95% CI:1.29–2.97). Squamous cell carcinoma was significantly less frequent among patients with bone metastases (13.0% vs. 29.8%; p=0.0004; OR=0.35; 95% CI: 0.19–0.64). The median survival time after the first bone metastasis diagnosis was four months. ConclusionAdenocarcinoma was the most common histological subtype of lung carcinoma and was significantly associated with a higher risk of developing bone metastases.