Abstract
O. Harold Warwick graduated in medicine from McGill University as a gold medalist and Rhodes Scholar in 1940. After World War II, he started postgraduate training in Montreal, and in 1946, he began studying the newly described drug treatment of cancer in London, England. There he carried out the first study of nitrogen mustard in a group of adult patients with a non-hematologic solid tumour, lung cancer. After a brief period of practice in Montreal, he moved in 1948 to Toronto, where he became executive director of the Canadian Cancer Society and the National Cancer Institute of Canada. Simultaneously, he joined the staff of Toronto General Hospital and its Radiotherapy Institute, where he became the first physician-oncologist to provide medical care and administer anticancer drugs in a Canadian cancer centre. In 1958, the new Princess Margaret Hospital opened in Toronto; Warwick became its first chief physician, responsible for clinical drug trials. Here he carried out his best known clinical study-the use of vinblastine sulphate in patients with Hodgkin lymphoma. From 1961 to 1971, he served as dean and then vice-president Health Sciences at the University of Western Ontario. He returned to the practice of medical oncology from 1972 to 1980 at the London Cancer Clinic, after which he had a long and productive retirement. He died in October 2009. Although the specialty was not named until the latter years of his career, Harold Warwick satisfied all the criteria for and was undoubtedly Canada's first medical oncologist.
Highlights
The genesis of modern medical oncology dates to the anticancer chemotherapy era, which in turn began with clinical studies that started in 1942 in the United States and Britain
The first patient in the United States was treated in December 1942, as discussed in a historical account of nitrogen mustard and the origin of chemotherapy 1
It was at this point that he decided to involve himself in the study and care of patients with cancer. He was aware of the nitrogen mustard story and the reported usefulness of hormone manipulation in patients with certain malignancies. His objective was to learn about these hormones and chemicals and to become involved in a newly developing field of medicine, the chemotherapy of cancer, which years later, under the name “systemic therapy,” became an integral part of medical oncology
Summary
The genesis of modern medical oncology dates to the anticancer chemotherapy era, which in turn began with clinical studies that started in 1942 in the United States and Britain. Those studies demonstrated the usefulness of nitrogen mustard in treating certain malignancies of the blood and lymphatic system. During the 1940s, investigators demonstrated the benefits of hormone manipulation in patients with prostate 6 and breast cancer 7 Those publications stimulated the interest of a young World War II veteran of the Royal Canadian Air Force Medical Corps: Orlando Harold Warwick, known as Harold
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