O–H bond activation of β,γ-unsaturated oximes via hydrogen atom transfer (HAT) and photoredox dual catalysis

Abstract

Activating O–H bonds in β,γ-unsaturated oximes is challenging due to high redox potential. Our method combines HAT and photoredox catalysis to allow the synthesis of diverse heterocycles using various radical acceptors. Mechanistic studies support the HAT process in O–H bond activation.