Abstract
ABO blood groups have recently been related to COVID19 infection. In the present work, we performed this analysis using data from 412 COVID19 patients and 17796 blood donors, all of them from Gipuzkoa, a region in Northern Spain. The results obtained confirmed this relation, in addition to showing a clear importance of group O as a protective factor in COVID19 disease, with an OR = 0.59 (CI95% 0.481-0.7177, p<0.0001) while A, B and AB are risk factors. ABO blood groups are slightly differently distributed in the populations and therefore these results should be replicated in the specific areas with a proper control population.
Highlights
COVID19 is a pandemic disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
One of the associated loci in chromosome 9, point to an association between ABO blood group and risk of infection by SARS-CoV-2. This association with the ABO blood group has been previously reported in other series showing that Group A is a risk factor while Group O seems to be a protective factor against SARS-CoV-2 infection
In line with the published works, our results show a higher frequency of group A in COVID19 patients when compared to control group, in this case Basque population, (48.3% vs 40.65%, p = 0.00179), while group O is less represented (39.08 vs 52.19%, p
Summary
COVID19 is a pandemic disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This disease has rapidly become the most important world health challenge in the last century. Several biomarkers have been proposed as risk or protective factors. In this scenario, a recent paper, demonstrating the importance of collaborative networks, presents the results of a Genome-wide analysis focused on COVID19 patients [1]. One of the associated loci in chromosome 9, point to an association between ABO blood group and risk of infection by SARS-CoV-2. This association with the ABO blood group has been previously reported in other series showing that Group A is a risk factor while Group O seems to be a protective factor against SARS-CoV-2 infection
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