O equilíbrio de Hardy-Weinberg no sistema sanguíneo ABO: um estudo de caso em Engenheiro Coelho – SP

Abstract

The genetics of human populations is the branch of Genetics that studies the dynamics of genes in natural populations, aiming at the elucidation of mechanisms that alter their genetic composition. Among the fundamentals of this science is the Hardy-Weinberg Equilibrium, which determines that gene frequencies remain unchanged and genotypic proportions reach a stable balance, obtaining the same constant relation with each other over time. To demonstrate this principle, it is necessary to admit that the studied population is not subject to evolutionary factors or to those that alter genotypic frequencies, increasing the homozygosity. More specifically, it is necessary to assume that the population obeys the following premises: random mating, infinite population, non-overlapping generations, in addition to the absence of mutation, selection and migration. More than recalling basic concepts of Genetics and Statistics, this article aims to describe the Bernstein Method for verifying the gene equilibrium for blood types. The research is concluded with a case study in the city of Engenheiro Coelho - SP, where the Hardy-Weinberg Equilibrium for blood types in the population is verified.