Abstract
AbstractThe antitumor activity of o‐carboxybenzoylferrocene sodium salt (1) was studied in vivo. Interaction between o‐carboxybenzoylferrocene (2) and N,N′‐carbonyldiimidazole in boiling methylene dichloride leads to 3‐(N‐imidazolyl)‐3‐ferrocenylisobenzofuran‐1(3H)‐one (5). The structure of compound 5 was established by X‐ray analysis. Aminolysis of compound 5 in toluene gave rise to ferrocenoylbenzamides (6a–d)–derivatives of dimethylamine, piperidine, pyrrolidine and morpholine. Copyright © 2008 John Wiley & Sons, Ltd.
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