Abstract

The In vitro maturation (IVM) of human oocytes has been a major focus in human assisted technology; however, despite of the improvement on IVM in the last years, the matured oocytes present significantly lower developmental competence than oocytes matured in vivo. Some studies showed that birefringent meiotic spindle can be detected in almost 50% of the oocytes that had extruded the first polar body (PB1) after IVM. Oocytes in which the meiotic spindle fails to be visualized may be immature, even when the PB1 is present in the periviteline space.

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