Abstract
Abstract At the moment of union in fertilisation, sperm and oocyte are transcriptionally silent, but little is understood about how transcription initiates in the newly-formed embryo. In this talk, I shall suggest why this fundamental process has remained arcane for so long, and how my lab has sought to unlock its secrets in mouse and human embryos. By combining micromanipulation and single-cell RNA-sequencing, we have revealed a programme of embryonic transcription initiation beginning within four hours of fertilisation in the mouse. The talk will outline our efforts to characterise this initiating transcription, and its conservation in human one-cell embryos. Transcribed genes predict regulation by oncogenic factors, including c-Myc, whose features will be detailed, together with a model suggesting predictive parallels between the onset of embryogenesis and cancer. Trial registration number XXXX
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