O-1-06. Relationships between sympathetic skin responses and 123I-etaiodobenzylguanidine myocardial scintigraphy in neurological disorders

Abstract

While various neurological disorders show abnormalities of both skin and cardiac sympathetic nerve functions, their relationship and clinical relevance have not been fully clarified. We investigated the relationship between abnormalities of the sympathetic skin responses (SSR) and 123I-metaiodobenzyl-guanidine (MIBG) myocardial scintigraphy in neurological disorders. We recorded both of these examinations in 19 patients with Parkinson’s disease or dementia with Lewy bodies, 7 with multiple system atrophy, 7 with other parkinsonism and 10 with others diseases. We excluded the cases complicated with myelopathy or neuropathy. We analyzed the relationship between SSR and the heart/mediastinum (H/M) ratio of the delayed image of MIBG myocardial scintigraphy using Welch’s t -test and Pearson’s chi-square test. We defined abnormal SSR as dissipation in at least two limbs. The mean H/M ratio in the patients with abnormal SSR was significantly lower (1.76) than that in those with normal SSR (2.51; p = 0.0014 by Welch’s t -test). Chisquare test also showed a significant difference across the patient subgroups showing normal or abnormal SSR and H/M ratio (p = 0.0017). In conclusion, the peripheral sympathetic skin and heart nerves may be concomitantly involved in the systemic autonomic nervous disorders.