O-083a Coagulase-negative Staphylococcal Infections In Uk Neonatal Units (nnus)

Abstract

<h3>Background and aims</h3> Advances in neonatal intensive care have resulted in improved survival and outcomes of increasingly preterm and very-low-birth-weight (VLBW) neonates. Invasive interventions contribute to higher rates of infections in these infants. This study aims to describe infections with coagulase-negative Staphylococci (CoNS) in UK NNUs participating in a neonatal infection surveillance network (neonIN). <h3>Methods</h3> neonIN is a web-based surveillance system (www.neonin.org.uk). Details of CoNS cases between January 2010 and May 2014 were extracted. Episodes were considered clinically significant if the infant was treated with at least 5 days of appropriate antibiotics and CRP was &gt;10 mg/L. Repeated growth within 10 days was considered the same episode. <h3>Results</h3> 440 episodes met the study inclusion criteria (399 infants, 23 NNUs). Incidence was 7.7/1000 NNU-admissions. Baseline characteristics for these episodes are shown in table-1. Resistance data were available for 250/440 (56.8%) episodes with high rates of resistance to flucloxacillin 89.9% (169/188) and penicillin 94.4% (67/71) and moderate resistance to teicoplanin 20.3% (14/69). Susceptibility to vancomycin was high 98.3% (169/172). <h3>Conclusions</h3> To our knowledge, this is the largest reported cohort of neonatal CoNS infections. Most babies were &lt;34 weeks gestation and &lt;2000 g birth-weight and had a CVC in-situ which was removed in around half of episodes. Prevention, as well as improved strategies for identifying significant CoNS infections should be prioritised. On behalf of the Neonaotal Infectiion Surveillance Network (neonlN).