Abstract
Cats with kaolin-induced obstructive hydrocephalus were studied by ventricle-to-ventricle perfusion in order to determine the influence of pressure on CSF formation and ventricular volume. It was demonstrated that in the individual hydrocephalic cat CSF production decreases as perfusion pressure is elevated. The mean decrease in CSF formation was found to be 3.5%/cm H2O pressure. It is proposed that this reduction is due to an adverse effect of intraventricular pressure on choroidal plexus, ependyma and adjacent brain tissue.Ventricular volume was shown to increase as rapidly as the pressure, at a rate of 0.0906 to 0.1031 ml/cm H2O pressure. This increase is to a large extent at the expense of the brain, and reversible within a short period of time.From pressure-dependent changes in ventricular volume it was possible to calculate the bulk elastic modulus of brain tissue. Its mean value was 3.848·105 dynes/cm2 and most probably represents the elastic properties of the various components of brain tissue.
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