NYX-783, A Novel Positive Allosteric Modulator of the N-Methyl D-Aspartate Receptor, Increases NMDAR-Mediated Signaling in the Infralimbic Prefrontal Cortex to Facilitate Extinction Learning in PTSD-Relevant Rodent Models

Abstract

Treatment options for post-traumatic stress disorder (PTSD) are limited. N-methyl D-aspartate receptor (NMDAR) hypofunction in the prefrontal cortex (PFC) is implicated in the development and maintenance of PTSD through dysregulation of the cognitive control of emotion necessary for appropriate response to non-harmful stimuli.