Abstract
Kainate (KA)-induced responses were studied in acutely dissociated rat cortical neurons. KA elicited the inward currents with conventional whole-cell and nystatin-perforated patch recordings under voltage-clamp condition. An additional outward current was observed only with the perforated patch recording. The outward current was due to the activation of K + current by Ca 2+ passing through the KA channels. This K + channel was sensitive to both iberiotoxin and tetraethylammonium (TEA)-Cl. This K + channel may serve to limit the depolarization during excessive KA-mediated excitation.
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