Abstract
BackgroundEach year, more than 13.7 million people became an active case of tuberculosis and more than 1.5 million cases of TB patient will die. The association between TB and malnutrition is bi-directional, TB leads the patient to malnutrition, and malnutrition increases the risk of developing active TB by 6 to 10 times. Improving the nutrition of individual greatly reduces tuberculosis. The aims of this study were to assess the nutritional status and determinants of underweight among TB patients.MethodsA comparative cross-sectional study design was implemented. The sample size was calculated using 95% CI, 90% power, the prevalence of malnutrition in TB patients 50%,TB patients to TB free resident ratio of 3, the design effect of 2 and a 5% non-response rate. Systematic random sampling was used to select TB patients and simple random sampling technique was used to select TB free residents. The data were collected from July 2015–May 2018. The data were collected by interviewing the patient, measuring anthropometric indicators and collecting the stool and blood samples. The data were entered into the computer using Epi-info software and analyzed using SPSS software. Descriptive statistics were used to find the proportion of malnutrition. Binary logistic regression was used to identify the determinants of malnutrition.ResultsA total of 5045 study participants (1681 TB patients and 3364 TB free residents) were included giving for the response rate of 93.1%. The prevalence of underweight among TB patients was 57.17% (95% CI: 54.80, − 59.54%) and 88.52% of TB patients were anemic. The prevalence of malnutrition (underweight) among TB free residents was 23.37% (95% CI: 21.93–24.80). The nutritional status of TB patients was determined by site of infection AOR: 0.68 [0.49–0.94], sex of the patient AOR: 0.39 [0.25–0.56], residence AOR: 3.84 [2.74–5.54], intestinal parasite infection AOR: 7 [5.2–9.95], problematic alcohol use AOR: 1.52 [1.17–2.13].ConclusionHigh proportions of TB patients were malnourished. TB patients were highly susceptible to malnutrition and even a very distal reason for malnutrition in the community became a proximal cause for TB patients.
Highlights
Each year, more than 13.7 million people became an active case of tuberculosis and more than 1.5 million cases of TB patient will die
The mean age of the study participants was 28 years, 18 year was the youngest age of study participants, 1681 of the study participants was TB patients and 3364 of the study participants were TB free residents
Female constitute 53.9% (2721) of the study participants, 26% of the study participants were from the urban area, 90% of the study participants were Amhara by ethnicity and 96.7% of the study participants were Orthodox Christian believers
Summary
More than 13.7 million people became an active case of tuberculosis and more than 1.5 million cases of TB patient will die. Underweight is a malnutrition stage in which the body mass index (BMI) of adult scores less than 18.5 KG/M2 cuts-points [1, 2] It results from an imbalance between the supply of food and the body demands for the nutrients. The association between TB and malnutrition is bidirectional, TB predisposes the patient to malnutrition and malnutrition increases the risk of developing active TB by 6 to 10 folds [6,7,8,9,10,11]. One-quarter of TB in the world was as a result of malnutrition, improving the nutritional status of the individual decreases the risk of TB [12]. Malnutrition increases TB relapse and mortality [13,14,15,16,17,18,19,20]
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