Abstract
Modulation of the immune status by a nutritionally balanced diet containing different levels of the polyunsaturated fatty acids (PUFA), with total fat porviding 25–30 energy % (en %), was examined in 8 healthy men (29–44 years) living in a metabolic unit. For the first two weeks all subjects were fed a stabilization diet (PUFA 6 en %), and for the next 11 weeks the level of PUFA calories was 3.5 en % for 4 subjects and 12.9 en % for the other 4 subjects. The level of PUFA in the diet did not affect any of the indices of the immune status tested. In both dietary groups, several indices of the immune status including the numbers of circulating T and B lymphocytes and their in vitro proliferation in response to T as well as B cell specific mitogens increased significantly with time. The numbers of circulating neutrophils and the serum concentration of complement fraction C3 decreased significantly in both the groups. Blood leukocyte count, serum contcentrations of IgA, IgE, IgG, IgM, and C4 remained unchanged in both groups. The immune status of these men was improved during the experimental period. Possible reasons for this improvement might include reduction in calories from fat or balanced and adequate supply of other nutrients.
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