Nutritional factors in the genesis of severe acne

Abstract

The study involved 180 respondents aged 15 to 25 years. 90 of them were acne patients and 90 were control group. Calculation of total energy content of daily food ration and actual nutrition was carried out according to methods recommended by the WHO and adjusted for residents of the Republic of Kazakhstan.The first task was to establish statistically significant frequency and extent of imbalance of calories consumed with food, as well as to find out dietary constituents of young people with acne compared with their healthy peers. Correlation analysis was used in case if any nutritional factor showed authentic group differences in frequency and/or extent of imbalance. Correlation analysis enables to establish relationship between this nutrition factor and clinical severity of acne. Revealed authentic strong (rs>0.7) or medium noticeable (0.7 蠅rs>0.5) correlation relationships justified performance of dispersion analysis, which allowed to prove authentic influence of the food factor on genesis of severe acne, as well as to determine extent of the impact (η2). The research proved statistically significant impact of excessive intake of calories; η2 in males (η2m) is 0.43, in females (η2f) ‐ 0.42, carbohydrates (η2m=0.23; η2f=0.35), animal fats (η2m=0.43; η2f=0.50). Deficit of vitamin A and carotene in the daily food ration has significant pathogenic effect on development of severe forms of acne (value of η2 in young men is 0.44 and 0.42 respectively, in girls‐0.46 and 0.31). Lack of vitamin D2 in food ration of young males also significantly potentiates inflammatory process (η2m=0.3). Pathogenic significance of folate deficiency in the diet of acne patients was detected only in males; while the impact is small (η2m=0.19). Deficiency of zinc in the diet induces severe forms of acne (η2m=0.44; η2f=0,34).