Abstract
This study was aimed to estimate the antioxidant, anti-diabetic, anti-amnesic, anti-biofilm, thrombolytic, hemolytic, and cytotoxic effects of G. glabra root extracts for nutritive and medicinal purpose. Antioxidant, alpha amylase, antiglycation, anti-amnesic, cytotoxic, thrombolytic and antibiofilm assays were performed. In the current research, G. glabra root extracts showed significant antioxidant (80.96 mg GAE/100 g TPC, 38.96 mg CE/100 g TFC, 46% DPPH scavenging), antidiabetic (75% antiglycation, 38.7% α-amylase inhibition), anti-amnesic (5.5%), hemolytic (19.46%), thrombolytic (35.4%) and antibiofilm (72% P. multocida, 51.57% S. aureus inhibition) activities. G. glabra root extracts have remarkable activity to fight against oxidative stress, hyperglycemia, blood coagulation, bacterial growth, DNA damage and memory enhancing ability that ensure its uses in food and pharmaceutical industries.
 Asian J. Med. Biol. Res. June 2019, 5(4): 265-270
Highlights
Glycyrrhiza glabra L. is among one of the active valuable plant used worldwide because of its healthcare and nutritional values
Our results are comparatively similar to these earlier findings, variations may be due to different solvents used and units of measurement used
Maximum flavonoid contents were shown by chloroform extract (38.96 ± 0.017 mg CE)
Summary
Glycyrrhiza glabra L. is among one of the active valuable plant used worldwide because of its healthcare and nutritional values. Roman, Greek, Chinese and Egyptian civilizations used its dried roots in soups, drinks and teas (Sharma and Agrawal, 2013). It is enriched with biologically active components such as starch, pectin, gum, mucilage, terpenes, saponins, flavonoids, bitters, asparagine, sex hormones (estrogen and progesterone), tannin, resins and sterols that represent 40-50% dry weight of G.glabra (Parvaiz et al, 2014). Medicinal potential and nutritional efficacies of G. glabra has been broadly assessed but investigation on some vital biochemical parameters of its root part are missing. The current research aims to reveal the selected bioactive potential of G. glabra roots to eradicate hyperglycemia, reactive oxygen species, psychomotor abnormalities, cytotoxicity, blood clot and bacterial infections
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