Nutritional and metabolic determinants of insulin resistance in adults

Abstract

The relations among insulin resistance (IR) and chronic inflammation with dietary habits have been scarcely defined. PURPOSE: To associate insulin resistance with dietary, anthropometric and other components of Metabolic Syndrome (MS) in adult subjects. METHODS: Cross-sectional study of 80 adult subjects (58+8yrs, 70%F; 30%M), were clinically and ethically selected. They all were assessed for anthropometry, dietary habits and plasma biochemistry. After diagnosed for MS (ATPIII, 2001) and divided into quartiles of HOMA-IR values (G1-P25<0.97; G2-P25-P75 and G3-P75>2.51) the values were statistically correlated with all other variables. The predictors of IR were determined by multivariant regression. RESULTS: HOMA-IR was significantly(P<0.001) associated with MS (r=0.67), hsCRP (r=0.58), waist circumference (WC) (r=0.55), ingested portions of oil (r=0.52), body weight (r=0.43), BMI (r=0.40) and uric acid (r=0.40) and inversely with HDL (r=−0.56), ingested fibers (r=−0.47) and fruits (r=−0.39). The fiber ingestion discriminated the quartiles of HOMA-IR (G1<G2<G3). Presence of SM, higher WC, BMI, ingested oil, uric acid and lower fiber intake and muscle mass were considered as independent variables for predicting HOMA-IR. CONCLUSIONS: Besides MS and obesity IR was associated with low muscle mass and inadequate intake of oil, refined cereal, fibers and fruits. Supported by CNPq/CAPES/FAPESP.