Abstract
Chronic kidney disease is a common disease in dogs, and factors such as serum concentrations of creatinine, albumin, and phosphorus at the moment of diagnosis may influence the survival of these patients. The present retrospective study aimed to evaluate the relationship between survival in dogs with chronic kidney disease and laboratory parameters (creatinine, phosphorus, albumin, and hematocrit) and nutritional parameters (body condition score, muscle mass score, type of food, appetite and feeding method). A total of 116 dogs with chronic kidney disease stages 2 to 4 were included, and survival was calculated considering the time between diagnosis and death. Survival curves were configurated by Kaplan-Meier analysis and a comparison between survival curves was performed by the log-rank test. Factors related to survival were disease stage (p<0.0001), serum phosphorus concentration (p = 0.0005), hematocrit (0.0001), body condition score (p = 0.0391), muscle mass score (p = 0.0002), type of food (p = 0.0009), feeding method (p<0.0001) and appetite (p = 0.0007). Based on data obtained in this study, it is possible to conclude that early diagnosis, as well as nutritional evaluation and renal diet intake, are determinant strategies to increase survival in dogs with chronic kidney disease.
Highlights
MethodsThis study was approved by the Animal Use Ethics Committee from the School of Veterinary and Animal Science of the University of Sao Paulo (FMVZ/USP), protocol number 3138/2013
Data Availability Statement: All relevant data are within the manuscript
Nutritional and laboratory parameters affect the survival of dogs with chronic kidney disease disease, the present study aimed to evaluate the influence of laboratory and nutritional parameters in the survival of dogs with Chronic kidney disease (CKD)
Summary
This study was approved by the Animal Use Ethics Committee from the School of Veterinary and Animal Science of the University of Sao Paulo (FMVZ/USP), protocol number 3138/2013. Information was obtained retrospectively from records of dogs assessed between February 2013 and December 2018 by the Veterinary Nutrology Service of the Teaching Hospital of the School of Veterinary Medicine and Animal Science from the University of Sao Paulo, Brazil. Inclusion criteria were dogs with 12 months of age or older, with serum creatinine concentrations above 1.4mg/dL for more than three months and urine specific gravity of 1.030 or lower, which characterizes animals diagnosed with CKD stages 2 and up [10]. Information obtained from the records at the time of diagnosis were: age; breed; body weight; BCS [20]; MMS [21]; hyporexia or anorexia; if feeding tubes were used; serum concentrations of creatinine, albumin, phosphorus, and urea; and percentage of hematocrit
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