Nutritional and clinical efficacy of ornithine alphaketog-ketoglutaratein severe burn patients

Abstract

Ornithine α-KetogIutarate (OKG) displays anabolic and anticatabolic properties in situations of stress. However, studies including both biological and clinical end points are scarce. In this prospective, randomized and double-blind study, 60 patients who had undergone severe burns (20-60% of body surface area) received either ornithine α-ketoglutarate (20 g/day) or an isocaloric placebo, for 21 days, starting mean 4 days after injury. In the OKG group, nitrogen balance reached positive values at d5 and stabilized at higher levels vs controls ( P < 0.05 or less from day 3 to day 21), resulting in a strongly positive cumulated nitrogen balance at day 21 (mean ± SEM, OKG group: +127 ± 13; Control group: −63 ± 18 g nitrogen). As measured at day 21, transthyretin and RBP levels were higher in the OKG group (respectively 259 ± 9 vs 161 ± 10, and 45 ± 1 vs 33 ± 1 mg/l, P < 0.001). Body weight loss was counteracted at d21 in the OKG group (−2.6% vs −6.3%, P < 0.001). Assessment of the quality of wound healing using objective scoring showed better performances in the OKG group ( P < 0.05). The results suggest that improvement in nutritional parameters observed during the treatment of burn-injured patients with ornithine α-ketoglutarate allows better clinical recovery.