Abstract
Communities eating a western-like diet, rich in fat, sugar and significantly deprived of fibers, share a relevant increased risk of both metabolic and cancerous diseases. Even more remarkable is that a low-fiber diet lacks some key components—as phytates and inositols—for which a mechanistic link has been clearly established in the pathogenesis of both cancer and metabolic illness. Reduced bioavailability of inositol in living organisms could arise from reduced food supply or from metabolism deregulation. Inositol deregulation has been found in a number of conditions mechanistically and epidemiologically associated to high-glucose diets or altered glucose metabolism. Indeed, high glucose levels hinder inositol availability by increasing its degradation and by inhibiting both myo-Ins biosynthesis and absorption. These underappreciated mechanisms may likely account for acquired, metabolic deficiency in inositol bioavailability.
Highlights
Health Protection from Whole-Grain Cereals: Key Components beyond FiberThe protective role of a diet with a high content of fibers against the development of chronic diseases—including obesity, diabetes, polycystic ovary syndrome (PCOS), metabolic syndrome, cardiovascular diseases, and cancer—is well established [1,2,3,4]
Even more remarkable is that a low-fiber diet lacks some key components—as phytates and inositols—for which a mechanistic link has been clearly established in the pathogenesis of both cancer and metabolic illness
This negative feedback loop may eventually worsen the metabolic status of mammal cells, especially cancer and insulin-resistant cells that are tightly dependent on glucose metabolism [93]
Summary
The protective role of a diet with a high content of fibers against the development of chronic diseases—including obesity, diabetes, polycystic ovary syndrome (PCOS), metabolic syndrome, cardiovascular diseases, and cancer—is well established [1,2,3,4]. Adding InsP6 to the drinking water significantly reduced the number and depth of the colonic crypts, as well as the incidence of colon tumors (83% in controls versus 25% in rats treated with InsP6) [15] These preliminary results have been further strengthened by additional investigations, which evidenced that both InsP6 and Inositol play some appreciable anticancer effects in a number of in vitro and in vivo studies (reviewed in [16]). The present survey aims precisely to contribute to filling that gap
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