Nutritional Agonists of PPAR-γ: An Immunomodulatory Approach to Control Cytokine Storm in Covid19 Patients

Bhavana Potluri,Nadeem Siddiqui,Shaik Mohammad Anjum,Sreedhar Bodiga,Sreeja Nannapaneni,Sri Sarvani Vemuri,Suryanarayana Veeravilli,Vijaya Lakshmi Bodiga

doi:10.9734/jpri/2021/v33i52a33562

Abstract

Recent examinations express that multi organ failure is seen in Corona virus infected patients with different pathway. It has been shown in contemplates that increased levels of cytokines like IL-1B and INF gamma were observed. It is called as cytokine storm with higher convergences of CCL2 and CXCL10. The cytokine storm is trailed by our immune system attacking own body which thus may cause numerous organ abnormalities and conclusive outcome being death. There is currently no specific treatment for viral illness, and this methodology is an optional path for focusing on specific qualities that may diminish cytokine storm. In such manner Peroxisome Proliferators Activated Receptors (PPARs) have a place with group of transcription factors which are known to manage the inflammatory mechanisms in body. This immunomodulatory approach is intended to focus PPAR-gamma ligands and their molecular docking studies. The activation or increased expression levels of PPAR gamma because of chosen agonists may reduce the cytokine storm in the covid patients. Thus, this is one such fascinating way to deal with neutralization of the cytokines exorbitantly elevated by use of substances like pomegranate, lemon grass and so on to activate PPARs reliably.

Highlights

The higher rate of mortality due to the corona virus outbreak has become a major threat to public health and number of cases is expected to grow exponentially [1]
Recent examinations express that multi organ failure is seen in Corona virus infected patients with different pathway
The remarkable role of Peroxisome Proliferators Activated Receptors (PPARs)-gamma increased expression cooperates in reducing the cytokines risk [9]

Summary

Introduction

The higher rate of mortality due to the corona virus outbreak has become a major threat to public health and number of cases is expected to grow exponentially [1]. Mononuclear inflammatory cells accumulation, pneumonocyte hyperplasia and alveolar damage are observed in patients infected severely with corona virus [2]. There are many mechanisms that are associated with the of the viral diseases and one among them is cytokine storm that causes threat to the patients [3]. The modulation of the aggressive release of the cytokines is important to reduce the multi-organ dysfunction in corona virus infected patients. When there is no known cure for corona virus infection, it is critical to investigate all other treatment options [8]. The remarkable role of PPAR-gamma increased expression cooperates in reducing the cytokines risk [9]

Methods

Results

Conclusion