Nutrition Studies in the Cold. II. Curative Effect of Cold on Fat Fatty Livers.

Abstract

Summary1) Three groups of young male rats received one of 3 different choline and inositol-free hypolipotropic diets for 21 days at 25°G. Seven rats of each group were then sacrificed. The remainder were continued on the same diet but divided into two subgroups; one was maintained at 1°G, the other at 25°G for an additional 28 days. The livers of all animals were analyzed for total lipids. 2) Data on food intake, growth rate, protein efficiency ratio, and liver weight confirmed earlier findings. The levels of liver lipids after 28 days at 1°G were lower in the 3 dietary groups than in either the comparable groups at 25°G after the initial 21 days or after the following 28 days. The results demonstrate that cold has a curative effect on the fat fatty liver and confirm earlier observations on the preventive effect of cold.