Nutrition Parameters for Assessing Malnutrition in a Population of US Veterans With Hepatitis C Virus

Abstract

Chronic liver disease often leads to malnutrition in patients. Patients with hepatitis C virus (HCV) are at greater risk for misclassification due to disease-specific changes in fluid, muscle, and fat status. Tools traditionally used to diagnose malnutrition may not be applicable in the HCV population, and delaying malnutrition diagnosis may contribute to disease progression. The aim of the present study is to determine and compare the incidence of malnutrition in US veterans with HCV by using 3 different malnutrition assessment tools (subjective global assessment [SGA], American Society for Parenteral and Enteral Nutrition and the Academy of Nutrition and Dietetics [ASPEN-AND], and Royal Free Hospital Global Assessment [RFH-GA]). Thirty-three US veterans were evaluated for malnutrition according to SGA, ASPEN-AND, and RFH-GA protocols using a prospective, descriptive study design. Fifteen participants (45.5%) were classified with malnutrition using any criteria (SGA, ASPEN, or RFH-GA). All 3 tools had good agreement, with ASPEN-AND to RFH-GA having the highest specificity and sensitivity. Of those classified with malnutrition using any assessment tool, mean body mass index was 26.6 (P = .014), subjective muscle loss was the most frequently encountered parameter, and 6 (40%) of 15 also had fluid accumulation. The results indicate that malnutrition and particularly muscle wasting is common in US veterans with HCV. All 3 tools had good agreement and the most commonly used nutrition parameter was muscle loss (subjective). In a malnutrition assessment tool for the HCV population, both subjective and objective measures of body composition should be included.