Abstract
Nutrition can be involved in the pathogenesis of psychotic disorders in a complex way. Nutrition deficiency syndromes in the matured adult brain are well studied, and have contribution considerably to the understanding of the biochemical bases of psychiatric illness. The importance of nutritional substances like the vitamins and trace elements in the development of psychotic disorders is stressed particularly by orthomolecular psychiatry. From the nutritional-metabolic point of view, a considerable number of hypotheses have arisen and discusses the findings concerning the metabolic and nutritional basis of schizo-affective psychoses. It can be concluded that a subtype of the schizo-affective disorders is caused by a disturbed serineglycine metabolism, which may result in the endogenous synthesis of hallucinogenic substances. This group of schizo-affective disorders can be distinguished from others by the presence of vivid perceptual anomalies. Dietary factors, such as catabolism, or an excess of serine and/or glycine contribute to the outbreak of this typical psychosis in susceptible persons, whereas a high carbohydrate, low protein, and low fat diet appears to be beneficial to these patients.
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