Abstract
Background and objectives: Total parenteral nutrition (TPN) has great clinical importance in malnutrition treatment and prevention in patients with digestive problems. Although good practices for handling TPN are well established, contamination of these products still occurs, and this product remains listed as a higher risk drug by the Institute for Safe Medication Practices. The present study aimed to obtain an overview of the documentary data of the parenteral nutrition samples sent to the National Institute for Quality Control in Health (INCQS) of Fundação Oswaldo Cruz. Methods: This is a qualitative descriptive and quantitative study carried out based on a cross-section of TPN samples analyzed from 2000 to 2016. Results: A total of TPN 134 samples were sent during the study period. 11.20% of the samples were sent in 2001, 0.80% in 2005, 8.20% in 2006, 16.40% in 2007, 63.40% in 2013. Six samples (4.5%) were canceled and 113 submitted to sterility testing, resulting in 13.3% unsatisfactory samples. Conclusion: During the study period, four suspected events of enterobacterial contamination in TPNs administered to patients were reported, three of which have not yet been described in the scientific literature. For the safety of patients using TPN to be guaranteed, it is suggested that the norms that regulate TPN therapy be reviewed and updated, and programs to monitor the quality of these preparations should be established.
Highlights
Total parenteral nutrition (TPN) has great clinical importance in the treatment and prevention of malnutrition when patients present a condition that does not allow them to absorb and digest food through the digestive system
According to the data survey, a total of 134 TPN samples were sent to INCQS from January 2000 to December 2016
The present study showed an overview of the characteristics and data associated with the TPN samples sent for analysis at INCQS over a 17-year period
Summary
Total parenteral nutrition (TPN) has great clinical importance in the treatment and prevention of malnutrition when patients present a condition that does not allow them to absorb and digest food through the digestive system. TPN is an extemporaneous product, not subjected to terminal sterilization, which makes the production process critical. These preparations must be produced and handled under aseptic conditions according to the parameters established by standards. Total parenteral nutrition (TPN) has great clinical importance in malnutrition treatment and prevention in patients with digestive problems. The present study aimed to obtain an overview of the documentary data of the parenteral nutrition samples sent to the National Institute for Quality Control in Health (INCQS) of Fundação Oswaldo Cruz. Results: A total of TPN 134 samples were sent during the study period. For the safety of patients using TPN to be guaranteed, it is suggested that the norms that regulate TPN therapy be reviewed and updated, and programs to monitor the quality of these preparations should be established
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