Abstract
Metabolomics is the study of low-weight molecules present in biological samples such as biofluids, tissue/cellular extracts, and culture media. Metabolomics research is increasing, and at the moment, it has several applications in the food science and nutrition fields. In the present review, we provide an update about the most frequently used methodologies and metabolomic platforms in these areas. Also, we discuss different metabolomic strategies regarding the discovery of new bioactive compounds (BACs) in plant-based foods. Furthermore, we review the existing literature related to the use of metabolomics to investigate the potential protective role of BACs in the prevention and treatment of non-communicable chronic diseases, namely cardiovascular disease, diabetes, and cancer.
Highlights
Non-communicable chronic diseases (NCCDs) are highly prevalent in both developing and developed countries [1]
It aims to review the current applications in food sciences and the existing evidence of nutrimetabolomics use, studying the effects of nutrients and certain bioactive compounds (BACs) that are present in plant-based foods such as vegetables, whole grains, legumes, fruits, and plant extracts on NCCDs outcomes
Among the techniques used in metabolomics studies, it is possible to find: gas chromatography-mass spectrometry (GC-MS), capillary electrophoresis coupled with mass spectrometry (CE-MS), liquid chromatography-mass spectrometry (LC-MS), and liquid and electrochemical chromatography-mass spectrometry (LC-EC-MS)
Summary
Non-communicable chronic diseases (NCCDs) are highly prevalent in both developing and developed countries [1]. The use of metabolomics in nutrition sciences, known as nutrimetabolomics, may be an attractive instrument for the identification of how nutrients and food BAC can interact and modulate metabolic diseases [17]. The objective of the present paper is to provide an update about the current knowledge of analytical technologies and approaches using metabolomics It aims to review the current applications in food sciences and the existing evidence of nutrimetabolomics use, studying the effects of nutrients and certain BACs that are present in plant-based foods such as vegetables, whole grains, legumes, fruits, and plant extracts on NCCDs outcomes
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