Abstract
Cancer occurs due to uncontrolled growth and proliferation of abnormal cells, which is a result of molecular alterations in genes associated with a variety of cellular processes. In order to support the development of incipient tumors, cancer cells are expected to require a constant and increasing supply of nutrients. Although it is evident that this increase in nutrients demand would be accompanied by adjustments in expression of genes associated with cellular nutrition, little is known about the regulation of these genes and its implication for cancer development and treatment. In this study a literature based list of 90 genes associated with cellular nutrition was compiled and used to stablish nutrigenomic expression signatures across the NCI-60 cancer cell line panel. In order to understand the possible interplay between nutrition genes and cancer genes a literature consolidated gene list of 119 cancer driver genes was used for analysis and comparison. Then, the public available NCI-60 data was used for correlations between nutrigenomic signatures, cancer driver genes and antineoplastic drugs. The results obtained showed several robust correlations between the gene lists and drugs. The expression of GPX2 (Glutathione Peroxidase 2 gene) was strongly correlated with several cancer driver genes and antineoplastic drugs, suggesting that GPX2 may play an important in cancer development and treatment.
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