Abstract

In Drosophila , growth in the germ line and its surrounding somatic follicle cells responds to the level of available nutrients. Insulin-like peptides produced in the brain are involved in this ovarian response to nutrition, but the mechanism of action is unknown. Using methods for the induction of insulin receptor mutant clones and analyzing mosaic ovarioles, LaFever and Drummond-Barbosa show that these insulin-like peptides directly affect the germline stem cells by regulating their rate of division and the rate of cyst growth. In contrast, follicle cells do not respond directly to insulin signals but instead receive a signal from the germ cells for coordinated growth. L. LaFever, D. Drummond-Barbosa, Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila . Science 309 , 1071-1073 (2005). [Abstract] [Full Text]

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