Abstract
BackgroundWe previously identified three distinct nutrient biomarker patterns associated with both psychometric and neuroimaging indices in a cross‐sectional analysis. The objective of this study was to examine the relationship between the nutrient biomarker patterns and cognitive decline over 2 years.MethodsThirty biological markers of diet were assayed in plasma drawn from 104 dementia‐free participants of the Oregon Brain Aging Study. Principal component analysis constructed 8 distinct nutrient biomarker patterns. A linear regression model was used to examine the change in the Clinical Dementia Rating ‐ sum of box score over two years explained by the nutrient biomarker patterns.ResultsMean age was 87±10, 62% are female, and 10% are carrying the ApoEe4 allele. Two distinct nutrient biomarker patterns were associated with rates of cognitive decline: a vitamin pattern high in vitamins B, C, E and D (p=0.001) and a high trans fat pattern (p<0.001) associated with less and more decline over two years, respectively. These findings were independent of age, gender, education years, ApoEe4 carrier status and vascular risk factors.ConclusionA nutrient biomarker pattern high in specific vitamins and low in trans‐fat may offer a prudent profile for promoting cognitive health in older populations. Funding: NIH/NCCAM AT004777 (GLB), NIH/NIA AG08017 (JAK), NIH/NCRR UL1 RR024140Grant Funding Source : NIH AT004777
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