Abstract
Introduction: Different clinical and molecular patterns of food allergy have been reported in different areas of the world. The aim of the study is to evaluate differences in allergen patterns among nut-allergic patients in two different areas of Spain. Material and methods: A total of 77 patients with nut allergy from two different regions of Spain (Madrid and Asturias) were evaluated. Results: Hazelnut, peanut, and walnut were the three most frequent nuts eliciting allergy in both regions, but in a different order. Patients from Madrid experienced systemic reactions more often than patients from Asturias (73.5% Madrid vs. 50.0%, p < 0.05). The percentage of sensitizations to LTP (Lipid Transfer Protein) was higher than Bet v 1 (p < 0.05) in the Madrid area. The percentage of sensitizations in Asturias area was similar to LTP than Bet v 1 (Pru p 3 46.4%, Bet v 1 42.9%, ns). Bet v 1 was the predominant allergen involved among hazelnut-allergic patients (56.2%), while LTP was more common in peanut-allergic patients (61.5%). Conclusion: Walnut, hazelnut, and peanut were the most frequent nuts eliciting allergy in Spain. Despite this, important differences in molecular pattern were appreciated not only between both regions, but also among nut-allergic patients in Asturias. The different molecular pattern was linked to the frequency of systemic symptoms.
Highlights
Different clinical and molecular patterns of food allergy have been reported in different areas of the world
In this study we describe differences in nut allergy in two different areas of Spain in which allergy was clearly associated with different molecular patterns of sensitization and differing risks of systemic symptoms
This study found that walnut, hazelnut, and peanut were the most frequent nuts eliciting
Summary
Different clinical and molecular patterns of food allergy have been reported in different areas of the world. The aim of the study is to evaluate differences in allergen patterns among nut-allergic patients in two different areas of Spain. Material and methods: A total of patients with nut allergy from two different regions of Spain (Madrid and Asturias) were evaluated. McWilliam et al [3] evaluated the prevalence of tree nut allergy in different regions of the world by means of a systematic review. The results of the study proved that prevalence of individual nut allergies varied significantly by region, with hazelnut being the most common tree nut allergy in Europe, walnut and cashew in the USA, and Brazil nut, almond, and Nutrients 2017, 9, 909; doi:10.3390/nu9080909 www.mdpi.com/journal/nutrients. Peanut allergy was the leading cause of death related to food-induced anaphylaxis in the United States [4]
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