Abstract
Postoperative bacterial infections are a major obstacle to patient recovery after total laryngectomy, and the development of antibiotics seemed to satisfactorily solve this problem. However, bacteria develop drug resistance to a large number of antibiotic drugs and form “superbugs,” which cause great harm to the public health. Based on this, the development of new antimicrobials has become the focus of research worldwide. In this study, we prepared a hyaluronic acid/silver nanocluster (HA/Ag NC) composite hydrogel based on a hyaluronic acid carrier and proved with clinical trials that it has an excellent antibacterial effect and can significantly reduce the incidence of inflammatory reactions in postoperative patients. In addition, the hydrogel effectively promotes the healing of surgical incisions and accelerates the proliferation of granulation tissue. As a result, the HA/Ag NCs compound hydrogel can offers a high-quality healing effect in patients after total laryngectomy.
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