Numerical study on temperature distribution during magnetic hyperthermia of different tumor tissues

Abstract

In recent years, nanotechnology has made an invasion in biomedical applications which has gained much more attention because of its high efficiency and low side effects.One such applicationis magnetic hyperthermia (MHT) where magnetic nanoparticles (MNPs) are used to generate heat to kill the cancerous tissues over an alternating magnetic field.The heat generated by the nanoparticles is caused by hysteresis and Neel and Brownian relaxation.In this paper, a finite element method-based numerical modelling with the help of COMSOL is used to obtain temperature distribution on different tumor tissues (liver, lungs, and kidney) embedded with nanoparticles during magnetic hyperthermia by varying different magnetic field strengths (4000–6000 A/m), different frequencies (100–500 kHz) and different volume fractions of nanoparticles (0.1––0.5 %). Results show that at 500 kHz frequency, the temperature at the centre of the tumor is elevated marginally by 8 %, 4 %, and 2 % for the lungs, liver, and kidney respectively. Similarly, at 6000 A/m magnetic field strength, the temperature at the given point of tumor enhances moderately by 25 %, 14 %, and 8 % in the case of lungs, liver, and kidney respectively. The temperature at the same location increases majorly by 81 %, 45 %, and 20 % for the case of lungs, liver, and kidney respectively at 0.5 % volume fraction of nanoparticles. In the study, the effect of the volume fraction of nanoparticles on temperature rise is found to be more significant compared to other cases. The heat transfer rate is maximum in the lungs followed by the liver and kidney respectively.