Abstract
Due to increased exposure to ultraviolet radiation caused by increased outdoor activities, the incidence of skin cancer is increasing. Incision is the most typical method for treating skin cancer, and various treatments that can minimize the risks of incision surgery are being investigated. Among them, photothermal therapy is garnering attention because it does not cause bleeding and affords rapid recovery. In photothermal therapy, tumor death is induced via temperature increase. In this study, a numerical study based on heat transfer theory was conducted to investigate the death of squamous cell carcinoma located in the skin layer based on various shapes of gold nanoparticles (AuNPs) used in photothermal therapy. The quantitative correlation between the conditions of various AuNPs and the laser intensity that yields the optimal photothermal treatment effect was derived using the effective apoptosis ratio. It was confirmed that optimal conditions exist for maximizing apoptosis within a tumor tissue and minimizing the thermal damage to surrounding normal tissues when using AuNPs under various conditions. Furthermore, it is envisioned that research result will be utilized as a standard for photothermal treatment in the future.
Highlights
Ultraviolet exposure has increased due to increased outdoor activities as a result of global economic development
Skin cancer can be primarily classified into squamous cell carcinoma, basal cell carcinoma, and malignant melanoma, and the treatment of these skin cancers is performed using various methods such as chemotherapy, cryotherapy, and incision [3,4,5]
Photothermal therapy is a treatment method that uses the photothermal effect, a phenomenon in which light energy is converted into thermal energy when light energy is irradiated onto a medium, to induce the death of tumor tissues by increasing the temperature of the target tumor tissue [13,14]
Summary
Ultraviolet exposure has increased due to increased outdoor activities as a result of global economic development. Photothermal therapy is a treatment method that uses the photothermal effect, a phenomenon in which light energy is converted into thermal energy when light energy is irradiated onto a medium, to induce the death of tumor tissues by increasing the temperature of the target tumor tissue [13,14]. This treatment method affords quick recovery and minimal risk of subsequent infection [15,16]. AuNPs reach the tumor in various ways such as direct administration and intravenous injection, and are injected into the tumor through a process such as endocytosis and used for treatment [24,25,26]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
