Numerical studies of hemodynamic alterations in pre- and post-stenting cerebral aneurysms using a multiscale modeling.

Abstract

The aim of this work was to use a multiscale modeling to study the influence of stent deployment, with generic stents, on flow distributions within the vascular network and the hemodynamic alterations within the cerebral aneurysms pre- and post-stenting. To achieve this goal, two image-based anatomical cerebral aneurysm models were reconstructed along with the respective aneurysms post-stenting models after deploying a 16- or 24-wire stent. The investigation results revealed that the stent may increase the local pressure resistance resulting in flow alterations. The hemodynamic parameters demonstrated stent placement can reduce the intra-aneurysmal pressure, decrease wall shear stress (WSS) at the neck region, and increase blood turnover time for aneurysm case I (sidewall aneurysm). These findings are consistent with the trends of hemodynamic changes reported previously. However, aneurysm case II (bifurcation aneurysm) showed gradually increased intra-aneurysmal pressure and the pressure at the neck region, decreased WSS over the sac surface, and enhanced flow vortices within the aneurysm. When simulating the hemodynamics of pre- and post-stenting aneurysms for a patient using measured flow waveforms, the flow alteration induced by the stent deployment may affect the hemodynamic predictions for the post-stenting aneurysm. Thus, the remeasurement of boundary conditions once the morphology of the aneurysm is deformed is needed in follow-up studies with a focus on aneurysm growth and stent deployment.