Numerical solution of optimal control of atherosclerosis using direct and indirect methods with shooting/collocation approach

Abstract

We present a direct numerical method for the solution of an optimal control problem controlling the growth of LDL (Low-density Lipoprotein), HDL (High-density Lipoprotein) and plaque. The optimal control problem is constrained with a system of coupled nonlinear free and mixed boundary partial differential equations consisting of three parabolics one elliptic and one ordinary differential equations. In the first step, the original problem is transformed from a free boundary problem into a fixed one and from the mixed boundary condition to a Neumann one. Then, employing a fixed point-collocation method, we solve the optimal control problem. In each step of the fixed point iteration, the problem is changed to a linear one and then, the equations are solved using the collocation method bringing about an NLP which is solved using sequential quadratic programming. Then, the obtained solution is verified using indirect methods originating from the first-order optimality conditions. Numerical results are considered to illustrate the efficiency of methods.