Numerical simulations of the nonsymmetric growth and remodeling of arteries under axial twisting

Abstract

Blood vessels are often subjected to axial twisting during body movement or surgery. Sustained twisting may lead to blood vessel growth and remodeling, however, it remains unclear how the extracellular matrix in the blood vessels remodel under sustained axial twisting. This study aimed to develop a computational model to simulate stress-induced growth and remodeling (G&R) of thin-walled blood vessels under axial twisting. Cylindrical vessels were subjected to a step increase in axial torque while the axial stretch and lumen pressure remained constant. The vessel walls were modeled based on the constrained mixture theory given as microstructure-based discrete fiber families with isotropic matrix structure models. Simulation results demonstrated that in response to a constant twist angle loading, arterial wall thickness, mass, and twisting torque gradually increase towards a new steady state. However, the stress and mass decrease in one diagonal fiber family while increasing in the other diagonal fiber family before reaching plateaus. A novel finding was that the two helical collagen fiber families showed different growth rates and patterns during remodeling, driven by the different fiber stresses generated by the twisting, and led to non-symmetric material properties. This study sheds new light on arterial wall remodeling under axial twisting.