Numerical Simulation on Behaviour of Magnetic Beads in Magnetic Filter for Medical Protein Screening System using High Gradient Magnetic Separation

Abstract

Recently, Antibody drugs are attracting attention in the medical field. Antibody using immune function has high efficacy and side effects are relatively few, so it is expected to become the mainstream of future medicine. Indispensable technologies for development of antibody drugs are continuous, large amount and high-speed separation of medical protein. Therefore, we have proposed superconducting high gradient magnetic separation (HGMS) system for medical protein. If HGMS system using superconducting magnet is realized, processing time of separation can be greatly shortened. In the previous studies, it was possible to separate 200 nm magnetic beads suspended in pure water, with the result that the capture ratio was 97.8% and the collection ratio was 94.1%. However, depending on the type of the suspension, the clogging of the magnetic filter and the phenomenon that the magnetic nano-beads are not trapped have been confirmed. Therefore, in this study, the magnetic force of the magnetic filter is evaluated by electromagnetic fluid and particle tracing analysis considering the behaviour of the magnetic beads two-dimensionally in the magnetic filter.