Abstract
After the model of sterilization area was established, numerical simulate was completed with fluent software. Verified with certain conditions of hot air velocity, the laminar flow tunnel oven is able to meet the relevant requirements of GMP. Under different speeds of hot air, the tunnel oven vials’ relationship between temperature and time, combined with analysis of pressure distribution inside the oven. When the air speed range from 0.6m/s to 1.5m/s, the temperature of vials meet the requirements and the minimum effect of negative pressure to oven.
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