Numerical optimization of the dual-wavelengths copper vapor laser treatment of basal cell cancer

Abstract

The use of a copper vapor laser (CVL) for the treatment of basal cell cancer (BCC) has allowed achieving highly effective elimination of BCC malignant cells without any recurrence for a long time after the procedure. According to recent translational medicine studies, the pathogenetic treatment of malignant skin diseases should include eliminating of not only pathological vascular bed, but also malignant melanocytes of the basal layer of the epidermis, promoting pathological development in the BCC involved area [1]. The targeted chromophore of melanocytes of the basal layer of the epidermis - melanin significantly differs in optical characteristics from the targeted chromophore of the vascular bed - oxyhemoglobin. Therefore, for the relevant pathogenetic laser treatment of BCC, it seems appropriate to use a dual-wavelengths laser exposure to CVL with wavelengths, one of which provides the high absorption by melanin (511 nm), and the other by oxyhemoglobin (578) nm. In this regard, it seems appropriate to use numerical modeling to analyze the effect of the relationship between the contribution of CVL radiation with a wavelength of 511 nm and a wavelength of 578 nm, taking into account the optical characteristics of the photoactive targets of the basal layer and blood in the pathological vascular bed of BCC.