Abstract
BackgroundThe effects of arterial wall compliance on blood flow have been revealed using fluid-structure interaction in last decades. However, microcirculation is not considered in previous researches. In fact, microcirculation plays a key role in regulating blood flow. Therefore, it is very necessary to involve microcirculation in arterial hemodynamics.ObjectiveThe main purpose of the present study is to investigate how wall compliance affects the flow characteristics and to establish the comparisons of these flow variables with rigid wall when microcirculation is considered.MethodsWe present numerical modeling in arterial hemodynamics incorporating fluid-structure interaction and microcirculation. A novel outlet boundary condition is employed to prescribe microcirculation in an idealised model.ResultsThe novel finding in this work is that wall compliance under the consideration of microcirculation leads to the increase of wall shear stress in contrast to rigid wall, contrary to the traditional result that wall compliance makes wall shear stress decrease when a constant or time dependent pressure is specified at an outlet.ConclusionsThis work provides the valuable study of hemodynamics under physiological and realistic boundary conditions and proves that wall compliance may have a positive impact on wall shear stress based on this model. This methodology in this paper could be used in real model simulations.
Highlights
As an important portion of circulatory system, microcirculation plays a key role and it should not be ignored
The novel finding in this work is that wall compliance under the consideration of microcirculation leads to the increase of wall shear stress in contrast to rigid wall, contrary to the traditional result that wall compliance makes wall shear stress decrease when a constant or time dependent pressure is specified at an outlet
This work provides the valuable study of hemodynamics under physiological and realistic boundary conditions and proves that wall compliance may have a positive impact on wall shear stress based on this model
Summary
As an important portion of circulatory system, microcirculation plays a key role and it should not be ignored. It serves to regulate blood flow and tissue perfusion thereby affecting blood pressure and responses to inflammation. As an important prognostic factor, microcirculation function plays a role in regulating blood flow to distal organs [3]. A specific pressure or velocity profile at an outlet is often given by a traditional approach in hemodynamic simulations. Microcirculatory effects could be addressed as outlet boundary conditions in hemodynamic simulations by a porous model, which is the likely best approach. Microcirculation plays a key role in regulating blood flow. It is very necessary to involve microcirculation in arterial hemodynamics
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
