Abstract
This thesis developed a numerical model based on the coarse-graining method to accurately and efficiently represent the changes in shape and deformability of ageing red blood cells during in vitro storage. The quality of the red blood cells declines during storage affecting the effectiveness of transfusion treatments, and this study discusses the recoverability of these changes in shape and deformability for achieving potential improvements to current storage practices for better transfusion outcomes. Further, this study is extensible to investigate the shape and deformability characteristics of healthy and diseased red blood cells for better diagnostics and treatments.↲
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