Numerical investigation of convective cooling in minimizing skin burns during radiofrequency ablation of breast tumor

Abstract

Skin burns is one of the most common complications reported during treatment of early-stage breast cancer with radiofrequency ablation (RFA) technique. In this regard, the present study aims to analyze the efficacy of forced convection surface cooling in minimizing the skin burns during RFA of breast tumor. The study considers a heterogeneous three-dimensional numerical model of breast that has been constructed based on the anatomical details available in the literature. A spherical tumor of 1.5 cm has been embedded in the numerical model of breast to represent in-situ tumor in its early stage. A programmable temperature-controlled RFA has been performed by incorporating the closed-loop feedback PID controller into the numerical model. The thermo-electric analysis has been performed using a finite element based commercial solver COMSOL Multiphysics® to obtain the temperature distribution by incorporating the coupled electric field distribution, Pennes bioheat equation and Arrhenius rate equation. The temperature dependent electrical and thermal conductivities of both the tissue and tumor along with damage dependent perfusion rate have been incorporated to achieve better correlation with the clinical RFA. The numerical simulation results revealed that, there is a significant reduction in the temperature at outer periphery of breast with increase in convective heat transfer coefficient. Further, the effects of variation in surface cooling on temperature distribution, input voltage requirement and treatment time required for complete tumor necrosis have been studied. The simultaneous application of forced convective surface cooling along with RFA could play a vital role in addressing the most common complication of skin burns during treatment of breast cancer.