Abstract
In this paper, a mathematical physiological model, Mackey–Glass system of a delay differential equation, is considered. With a greater delay, a periodic solution arises, which characterizes the disease of chronic granulocytic leukemia (CGL). To treat such disease, a blood transfusion feedback control is considered, from the point of view of mathematical control. By using a nonstandard finite-difference (NSFD) scheme to the control system, we obtain a numerical discrete system and analyze its Neimark–Sacker and fold bifurcations. The results imply that the condition of the illness could be relieved by transfusing blood to the patient, if the control is a delay control. Finally, the effectiveness of the control are illustrated by several numerical simulations.
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