Abstract
An improved cryopreservation method is the need of the hour in the medical field to control the freezing rate to prevent the damage of biological tissues. The present article addresses two issues. First, a numerical model is developed for cryopreservation of biological tissues where non-Fourier heat conduction plays an important role in predicting the freezing rate. A new version of enthalpy method is then proposed and applied for capturing the freezing front. Secondly, with the addition of MgO nanoparticles, which are biodegradable, biocompatible, and nontoxic, the enhancement of freezing rate is explored. The temperature field at different points in the domain is studied. The effect of the different volume fraction of nanoparticles on the freezing rate is discussed in detail. It is observed that the blood perfusion rate has a significant role in predicting the freezing rate.
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