Numerical Analysis for Tableting Process in Consideration of Compression Speed

Abstract

A numerical study of the tableting process using a finite element method (FEM) is important to quantitatively understand the structural change inside the tablet and the mechanism of tableting failures such as capping, picking, lamination, and sticking. In the pharmaceutical field, the Drucker-Prager Cap (DPC) model is used most widely to demonstrate the mechanical behavior of the powder during tableting. The DPC model, however, cannot consider compaction speed, although the compaction speed has a large impact on the tablet strength and tableting failures. In our present study, a DPC–Perzyna model, which incorporates a visco-plastic behavior considering the compression speed, was proposed. Here, the DPC–Perzyna model was outlined and typical results obtained by the DPC–Perzyna model was presented.