Abstract

BackgroundPulmonary metastasectomy (PM) is an established treatment for selected patients with metastatic sarcomas. The aim of this study was to examine our institutional experience and evaluate factors predicting outcome.MethodsWe retrospectively reviewed all patients undergoing PM for bone sarcoma in our center from 2001 to 2019. Survival was calculated from the date of PM. Impact on survival of clinical parameters was assessed.ResultsThirty-eight patients (27 males, 71%) were included. Histology was osteosarcoma (n = 20, 53%), Ewing sarcoma (n = 13, 34%) and chondrosarcoma (n = 5, 13%). Twelve patients (31.5%) had synchronous metastases, all received chemotherapy before PM. Median number of metastases was 3 (1 to 29). Twenty (53%) patients had mediastinal lymph node sampling. One patient had positive lymph nodes. Ninety-day mortality was 0%. Three and 5-year PFS were 24.5 and 21%, respectively. Three and 5-year OS were 64.5 and 38.5%, respectively. More than three metastases and progression under chemotherapy were significant independent predictors for OS.ConclusionPM is a safe procedure and encouraging long-term outcome can be achieved. Patients with progression of pulmonary metastases under chemotherapy as well as patients with more than three metastases had significantly worse OS.

Highlights

  • Pulmonary metastasectomy (PM) is an established treatment for selected patients with metastatic sarcomas

  • Sarcomas are rare malignancies representing a heterogeneous group of tumors

  • Stork et al BMC Cancer (2021) 21:375 disease-free interval [4,5,6,7] have been described for patients with pulmonary metastases from osteosarcoma or chondrosarcoma

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Summary

Introduction

Pulmonary metastasectomy (PM) is an established treatment for selected patients with metastatic sarcomas. The aim of this study was to examine our institutional experience and evaluate factors predicting outcome. Sarcomas are rare malignancies representing a heterogeneous group of tumors. The incidence of primary bone sarcomas is approximately four to ten times lower than of soft tissue sarcomas (STS). Stork et al BMC Cancer (2021) 21:375 disease-free interval [4,5,6,7] have been described for patients with pulmonary metastases from osteosarcoma or chondrosarcoma. We aim to examine our institutional experience and evaluate factors predicting outcome after PM for bone sarcomas

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