Abstract

The COVID-19 pandemic beginning in 2020 is associated with more than 600 million documented cases and over 6 million deaths worldwide. Disease severity risk factors include old age, and diseases of the lung, cardiovascular, kidney and obesity. This review proposes chronic alcohol use disorder (AUD) as a risk factor for COVID-19 severity with evidence for three common pathologic mechanisms with these established COVID-19 risk factors that include microbiome dysbiosis, leaky gut and activation of the NLRP3 inflammasome driving systemic inflammation.

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