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Cover: In Sirois et al. (http://doi.org/10.1002/cpet.45), the image shows the CRISPR/Cas system. Bacteria and archaea use the CRISPR/Cas system for adaptive immunity against foreign viruses and plasmids. (1) Upon infection, foreign DNA is processed into small (∼20-bp) fragments which are (2) incorporated between palindromic repeats within the CRISPR locus. (3) The CRISPR locus, containing the spacers and trans-activating RNA (tracrRNA), is transcribed. (4) The spacer transcripts are processed to generate small CRISPR RNA (crRNA) molecules, which base pair with the tracrRNA to form a functional guide RNA (gRNA). (5) A Cas endonuclease protein complexes with the gRNA via the tracrRNA, and is guided to a specific target DNA by the crRNA. (6) Upon encountering the specific DNA sequence, the Cas protein will hybridize to, and cut, the double-stranded DNA, resulting in a double-strand break. Figure adapted from “CRISPR-Cas9 Adaptive Immune System of Streptococcus pyogenes against bacteriophages,” by BioRender.com (2020). Retrieved from https://app.biorender.com/biorender-templates.